Ozempic and Mounjaro: What to Expect, Side Effects, and How to Manage Them

If you're starting Ozempic or Mounjaro for weight loss or diabetes management, it's normal to wonder what the first few weeks will feel like. These medications can be effective, but they come with some side effects—especially in the beginning. Here's what you need to know.

What to Expect After Your First Dose of Ozempic

Ozempic is usually started at a low dose (0.25 mg) to help your body adjust. While it helps control blood sugar and reduce appetite, some early side effects are common.

What patients notice after the first dose of Ozempic:

  • Mild nausea – Most common side effect in the first few days

  • Decreased appetite – Hunger usually goes down quickly

  • Fullness or bloating – Food moves more slowly through your stomach

  • Fatigue or headache – Some people feel more tired or get mild headaches

Why it happens:

Ozempic acts like a natural hormone called GLP-1. It helps control blood sugar, slows digestion, and tells your brain that you're full. These effects take time to get used to.

Tip: Stick with small, simple meals (like toast, rice, or broth) and drink water throughout the day. Most side effects improve after a couple of weeks.

Does Mounjaro Cause Constipation?

Yes, Mounjaro can cause constipation, especially at higher doses. In studies, 11 to 18 percent of people reported it as a side effect.

Why it happens:

Mounjaro works on two hormones (GLP-1 and GIP) that both slow digestion. That can make your digestive system sluggish.

What it might feel like:

  • Fewer or harder bowel movements

  • Bloating or abdominal pressure

  • Feeling backed up

How to manage it:

  • Drink 8–10 glasses of water a day

  • Add fiber slowly (vegetables, fruit, fiber supplements)

  • Take walks or stay active

  • Ask your doctor about stool softeners or mild laxatives

Constipation usually improves as your body gets used to the medication.

Mounjaro Side Effects Overview

Here's what the studies show about common and less common Mounjaro side effects:

Common Side Effects (mild to moderate):

  • Nausea – 12% to 24%

  • Diarrhea – 12% to 17%

  • Decreased appetite – 6% to 16%

  • Constipation – 11% to 18%

  • Vomiting – 5% to 13%

  • Indigestion – around 9%

These are most likely to show up early in treatment or during dose increases. They usually improve over time.

Less Common but More Serious Side Effects:

  • Pancreatitis (inflammation of the pancreas)

  • Gallbladder problems (gallstones or inflammation)

  • Low blood sugar (especially with insulin or other diabetes drugs)

  • Allergic reactions (rash, swelling, itching)

  • Redness or irritation at injection site

Important safety note:

Mounjaro and Ozempic both have a warning about a possible risk of thyroid tumors (seen in animal studies). They are not recommended for people with a personal or family history of medullary thyroid cancer or MEN 2 syndrome.

Are These Medications Worth It?

For many people, yes.

  • Ozempic helps lower blood sugar and can lead to 10–15% weight loss in some patients

  • Mounjaro often leads to even more weight loss, thanks to its dual hormone action

These results are impressive, but they don't happen automatically. The best outcomes come when the medication is part of a full plan that includes healthy eating, regular activity, and follow-up care.

Final Thoughts

Ozempic and Mounjaro are not quick fixes, but they can be powerful tools when used correctly. Managing side effects early and staying consistent with your care makes a big difference.

If you're in Florida and looking for professional guidance, Khrom MedSpa & Weight Loss offers personalized support for patients using Ozempic and Mounjaro. Their programs include medical supervision, nutritional coaching, and long-term care to help you get the best results safely.

Key Takeaways:

  • Expect mild nausea, appetite changes, and possible constipation in the first few weeks

  • Eat small meals, drink water, and stay active to manage side effects

  • Monitor for serious reactions and stay in touch with your doctor

  • Choose a provider that supports you throughout the process

With the right plan, Ozempic and Mounjaro can help you take real steps toward better health and lasting weight loss.